![]() ![]() The dose should be increased gradually every two to four weeks according to the clinical findings and thyroid hormone and TSH values until the full replacement dose is reached. Thereafter, the dose should be adjusted individually according to the clinical findings and thyroid hormone and TSH values.įor children with acquired hypothyroidism, the initial recommended dosage is 12.5-50 micrograms per day. Infants should be given the total daily dose at least half an hour before the first meal of the day.įor neonates and infants with congenital hypothyroidism, where rapid replacement is important, the initial recommended dosage is 10 to 15 micrograms per kg body weight per day for the first three months. Regular monitoring using serum TSH levels, as in adults, is required to make sure he/she gets the right dose. The dose for children depends on their age, weight and the condition being treated. The maintenance dose is generally 100 to 150 micrograms per m 2 body surface area. The final daily dose may be up to 50 to 200 micrograms.įor patients aged over 50 years, with or without cardiac disease, clinical response is probably a more acceptable criteria of dosage rather that serum levels. In this condition, the daily dosage may be increased by 25 microgram increments at intervals of every 4 weeks, until stable thyroxine levels are attained. Where there is cardiac disease, 25 micrograms daily or 50 micrograms on alternate days is more suitable. Patients over 50 years with cardiac disease: The final daily dose may be up to 50 to 200 micrograms. In this condition, the daily dose may be increased by 50 micrograms at intervals of every 3-4 weeks, until stable thyroxine levels are attained. The final dose may be up to 100 to 200 micrograms.Įlderly: as for patients aged over 50 yearsįor patients over 50 years, initially, it is not advisable to exceed 50 micrograms daily. Adjust at three to four week intervals by 50 micrograms until normal metabolism is steadily maintained. If too rapid an increase in metabolism is produced (causing diarrhoea, nervousness, rapid pulse, insomnia, tremors, and sometimes anginal pain where there is latent cardiac ischaemia,) dosage must be reduced, or withheld, for a day or two, and then re-started at a lower dose level.Īdults: Initially, 50 to 100 micrograms daily (two to four tablets daily), preferably taken before breakfast or your first meal of the day. A pre-therapy ECG is valuable because ECG changes due to hypothyroidism may be confused with ECG evidence of cardiac ischaemia. In younger patients, and in the absence of heart disease, a serum Levothyroxine (T4) level of 70 to 160 nanomols per litre, or a serum thyrotrophin level of less than 5 milli-units per litre should be targeted. ![]()
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